{"id":5060,"date":"2025-06-21T22:04:21","date_gmt":"2025-06-22T01:04:21","guid":{"rendered":"https:\/\/elreportivo.cl\/olimpia\/?p=5060"},"modified":"2025-06-21T22:04:24","modified_gmt":"2025-06-22T01:04:24","slug":"5060","status":"publish","type":"post","link":"https:\/\/elreportivo.cl\/olimpia\/2025\/06\/21\/5060\/","title":{"rendered":""},"content":{"rendered":"\n<div class=\"wp-block-cover alignfull\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px;min-height:635px;aspect-ratio:unset;\"><img decoding=\"async\" class=\"wp-block-cover__image-background wp-image-168\" alt=\"\" src=\"https:\/\/elreportivodeolimpia.cl\/wp-content\/uploads\/2022\/08\/sports-tools.jpg\" data-object-fit=\"cover\"\/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-80 has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<div class=\"wp-block-media-text alignfull is-stacked-on-mobile is-vertically-aligned-center\"><figure class=\"wp-block-media-text__media\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/elreportivo.cl\/olimpia\/wp-content\/uploads\/2025\/06\/10-2-1024x576.jpg\" alt=\"\" class=\"wp-image-5063 size-full\" srcset=\"https:\/\/elreportivo.cl\/olimpia\/wp-content\/uploads\/2025\/06\/10-2-1024x576.jpg 1024w, https:\/\/elreportivo.cl\/olimpia\/wp-content\/uploads\/2025\/06\/10-2-300x169.jpg 300w, https:\/\/elreportivo.cl\/olimpia\/wp-content\/uploads\/2025\/06\/10-2-768x432.jpg 768w, https:\/\/elreportivo.cl\/olimpia\/wp-content\/uploads\/2025\/06\/10-2-1536x864.jpg 1536w, https:\/\/elreportivo.cl\/olimpia\/wp-content\/uploads\/2025\/06\/10-2.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n\n\n<p>\u00a0 \u00a0Un nuevo estudio descubri\u00f3 que un gen recientemente reconocido como biomarcador de la enfermedad de Alzheimer es en realidad una de sus causas, debido a su funci\u00f3n secundaria previamente desconocida. Investigadores de la Universidad de California en San Diego utilizaron inteligencia artificial para desentra\u00f1ar este misterio de la enfermedad de Alzheimer y descubrir un posible tratamiento que obstruya la funci\u00f3n secundaria de este gen.<\/p>\n<p>El equipo de investigaci\u00f3n public\u00f3 sus resultados en la revista Cell. \u00a0 \u00a0Aproximadamente una de cada nueve personas mayores de 65 a\u00f1os padece Alzheimer, la causa m\u00e1s com\u00fan de demencia. Si bien algunos genes espec\u00edficos, al mutar, pueden provocar Alzheimer, esta conexi\u00f3n solo afecta a un peque\u00f1o porcentaje de todos los pacientes con Alzheimer. La gran mayor\u00eda de los pacientes no presenta una mutaci\u00f3n en un gen causante de la enfermedad; en cambio, padecen Alzheimer &#8220;espont\u00e1neo&#8221;, cuyas causas no est\u00e1n claras.<\/p>\n<p>\u00a0\u00a0\u00a0 Descubrir esas causas podr\u00eda en \u00faltima instancia mejorar la atenci\u00f3n m\u00e9dica. \u201cDesafortunadamente, las opciones de tratamiento para la enfermedad de Alzheimer son muy limitadas. Y la respuesta al tratamiento no es excepcional en este momento\u201d, afirm\u00f3 Sheng Zhong, autor principal del estudio y profesor del Departamento de Bioingenier\u00eda Shu Chien-Gene Lay de la Escuela de Ingenier\u00eda Jacobs de la UC San Diego.<\/p>\n<p>\u00a0\u00a0\u00a0 Por ello, Zhong y su equipo analizaron m\u00e1s a fondo la fosfoglicerato deshidrogenasa (PHGDH), que previamente hab\u00edan descubierto como un posible biomarcador sangu\u00edneo para la detecci\u00f3n temprana de la enfermedad de Alzheimer. En un estudio posterior, descubrieron que los niveles de expresi\u00f3n del gen PHGDH se correlacionaban directamente con los cambios cerebrales en la enfermedad de Alzheimer; es decir, cuanto mayores eran los niveles de prote\u00edna y ARN producidos por el gen PHGDH, m\u00e1s avanzada estaba la enfermedad. Seg\u00fan Zhong, esta correlaci\u00f3n se ha verificado desde entonces en m\u00faltiples cohortes de diferentes centros m\u00e9dicos.<\/p>\n<p>\u00a0\u00a0\u00a0 Intrigado por esta correlaci\u00f3n reproducible, el equipo de investigaci\u00f3n decidi\u00f3 investigar en este \u00faltimo estudio si exist\u00eda un efecto causal. Utilizando organoides cerebrales de ratones y humanos, los investigadores descubrieron que alterar la expresi\u00f3n de PHGDH ten\u00eda efectos consecuentes en la enfermedad de Alzheimer: niveles m\u00e1s bajos se correspond\u00edan con una menor progresi\u00f3n de la enfermedad, mientras que niveles m\u00e1s altos conduc\u00edan a un mayor avance de la enfermedad. Por lo tanto, los investigadores establecieron que PHGDH es, de hecho, un gen causal de la enfermedad de Alzheimer espont\u00e1nea.<\/p>\n<p>\u00a0\u00a0\u00a0 Para respaldar a\u00fan m\u00e1s este hallazgo, los investigadores determinaron, con ayuda de IA, que la PHGDH desempe\u00f1a una funci\u00f3n desconocida hasta ahora: activa una v\u00eda que altera la activaci\u00f3n y desactivaci\u00f3n de genes en las c\u00e9lulas cerebrales. Esta alteraci\u00f3n puede causar problemas, como el desarrollo de la enfermedad de Alzheimer.<\/p>\n<p>Fuente: IA Academy News.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\"><\/div>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"has-text-align-right wp-block-post-date has-text-color has-ast-global-color-5-color has-background has-vivid-red-background-color has-medium-font-size\"><time datetime=\"2025-06-21T22:04:21-03:00\">21\/Jun\/2025<\/time><\/div><\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":5063,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"plain-container","ast-site-content-layout":"normal-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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