{"id":5274,"date":"2025-08-02T14:12:10","date_gmt":"2025-08-02T17:12:10","guid":{"rendered":"https:\/\/elreportivo.cl\/olimpia\/?p=5274"},"modified":"2025-08-02T14:17:08","modified_gmt":"2025-08-02T17:17:08","slug":"5274","status":"publish","type":"post","link":"https:\/\/elreportivo.cl\/olimpia\/2025\/08\/02\/5274\/","title":{"rendered":""},"content":{"rendered":"\n<div class=\"wp-block-cover alignfull\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px;min-height:635px;aspect-ratio:unset;\"><img decoding=\"async\" class=\"wp-block-cover__image-background wp-image-168\" alt=\"\" src=\"https:\/\/elreportivodeolimpia.cl\/wp-content\/uploads\/2022\/08\/sports-tools.jpg\" data-object-fit=\"cover\"\/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-80 has-background-dim\"><\/span><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<div class=\"wp-block-media-text alignfull is-stacked-on-mobile is-vertically-aligned-center\"><figure class=\"wp-block-media-text__media\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/elreportivo.cl\/olimpia\/wp-content\/uploads\/2025\/08\/10-1024x576.jpg\" alt=\"\" class=\"wp-image-5280 size-full\" srcset=\"https:\/\/elreportivo.cl\/olimpia\/wp-content\/uploads\/2025\/08\/10-1024x576.jpg 1024w, https:\/\/elreportivo.cl\/olimpia\/wp-content\/uploads\/2025\/08\/10-300x169.jpg 300w, https:\/\/elreportivo.cl\/olimpia\/wp-content\/uploads\/2025\/08\/10-768x432.jpg 768w, https:\/\/elreportivo.cl\/olimpia\/wp-content\/uploads\/2025\/08\/10-1536x864.jpg 1536w, https:\/\/elreportivo.cl\/olimpia\/wp-content\/uploads\/2025\/08\/10.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n\n\n<p>\u00a0 \u00a0\u00a0Una base de datos global revela c\u00f3mo las prote\u00ednas en la sangre reflejan el estado del cerebro, abriendo nuevas v\u00edas para el diagn\u00f3stico temprano y el desarrollo de terapias personalizadas.<\/p>\n<p>\u00a0\u00a0\u00a0 Las prestigiosas revistas Nature Medicine y Nature Aging presentan el resultado de una larga investigaci\u00f3n que podr\u00eda suponer un paso gigante en la detecci\u00f3n precoz y el desarrollo de terapias frente a las principales enfermedades neurodegenerativas, como lo son el alzh\u00e9imer, el p\u00e1rkinson, la demencia frototemporal y la esclerosis lateral amiotr\u00f3fica o ELA.<\/p>\n<p>\u00a0\u00a0\u00a0 El equipo logr\u00f3 identificar 2.000 prote\u00ednas asociadas a cada una de las tres enfermedades principales &#8211; alzh\u00e9imer, p\u00e1rkinson y demencia frontotemporal. Mediante t\u00e9cnicas de aprendizaje autom\u00e1tico, los cient\u00edficos pudieron aislar las diez prote\u00ednas m\u00e1s determinantes para cada dolencia, permiti\u00e9ndoles compararlas entre s\u00ed y con perfiles de envejecimiento sano.<\/p>\n<p>\u00a0\u00a0\u00a0 &#8220;Es la primera vez que podemos comparar estas enfermedades desde el punto de vista del perfil proteico, ver lo que tienen en com\u00fan y aislar lo espec\u00edfico de cada una&#8221;.<\/p>\n<p>\u00a0\u00a0\u00a0 Con este avance se prev\u00e9 que puedan desarrollarse diagn\u00f3sticos menos invasivos para estas enfermedades, pues hasta ahora, los biomarcadores se detectaban principalmente en el l\u00edquido cefalorraqu\u00eddeo. Con la posibilidad de identificarlos en sangre da comienzo una revoluci\u00f3n en accesibilidad y prevenci\u00f3n, indican.<\/p>\n<p>\u00a0\u00a0\u00a0 &#8220;Esos biomarcadores nos llevar\u00e1n a encontrar pacientes antes de que desarrollen la patolog\u00eda y, con ello, a poder cambiar sus prote\u00ednas por las de un perfil sano&#8221;, explica Cruchaga, uno de los investigadores, a la agencia Efe.<\/p>\n<p>&#8220;Estamos avanzando en la direcci\u00f3n correcta para desarrollar una nueva ola de terapias y ensayos frente a estas enfermedades&#8221;, responde el investigador a Efe. &#8220;Este solo es el comienzo, la punta del iceberg&#8221; de los resultados que producir\u00e1 este repositorio de datos de prote\u00ednas asociadas a estas enfermedades, agrega.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\"><\/div>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"has-text-align-right wp-block-post-date has-text-color has-ast-global-color-5-color has-background has-vivid-red-background-color has-medium-font-size\"><time datetime=\"2025-08-02T14:12:10-03:00\">2\/Ago\/2025<\/time><\/div><\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":5280,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"plain-container","ast-site-content-layout":"normal-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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